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Trial Details

  • Trial statusFollowup
  • Study email contactradical@imperial.ac.uk
  • Chief InvestigatorMichael Seckl
  • SponsorImperial College London
  • ISRCTN number80307982
  • PhaseIIa

A single arm phase IIa study (with combination safety run-in) to assess the safety and efficacy of AZD4547 in combination with either anastrozole or letrozole in ER positive breast cancer patients

Design and Objective

This is a phase IIa (with safety run-in), multi-centre, open label, single arm study of AZD4547 administered orally together with anastrozole or letrozole in ER+ breast cancer patients who have progressed on treatment with anastrozole or letrozole; in adjuvant or first line metastatic (safety run-in only) or any setting (phase IIa only). There are two parts to this study: an initial safety run-in followed by a phase IIa study

Key inclusion criteria

Written informed consent and ability to comply with study protocol Aged ≥ 25 years of age Post menopausal women with histological confirmation of breast cancer with documented positive oestrogen receptor status (ER+) of primary or metastatic tumour tissue Fulfils criteria for previous treatment of breast cancer

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