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IP4 – CHRONOS

Trial Details

Comparative Health Research Outcomes of Novel Surgery in Prostate Cancer

Design and Objective

Two linked open label, multicentre RCTs with choice of A or B dependent on physician and patient equipoise. CHRONOS-A: Two arm RCT to evaluate progression free survival rates of Focal Therapy (FT) compared to radical therapy (radiotherapy or surgery) in prostate cancer treatment. CHRONOS-B: Multi-Arm Multi-Stage RCT to evaluate failure free survival rates of FT alone compared to FT combined with other therapies.

Key inclusion criteria

Men over 18 years old with a diagnosis of medium risk prostate cancer or low risk cancer proven on biopsy. Participants should have an interest in undergoing Focal Therapy as a treatment for prostate cancer and be fit to undergo Radical Therapy or Focal Therapy without any previous prostate cancer treatments.

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