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Trial Details

  • Trial statusCompleted
  • Study email contactLEOPARDS@imperial.ac.uk
  • Chief InvestigatorProf Anthony Gordon
  • Project managerDr Farah Al-Beidh
  • SponsorImperial College London
  • ISRCTN numberISRCTN12776039
  • PhaseIIb

Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis

Design and Objective

This is a double-blind randomised placebo-controlled parallel group trial. It will be conducted in multiple general adult ICUs within the UK. The study will recruit 516 patients.

Key inclusion criteria

- Hypotension, despite adequate intravenous fluid resuscitation, requiring vasopressor infusion AND two of the following: - Fever (>38C) or hypothermia (<36C) - Tachycardia (heart rate >90 bpm) - Tachypnoea (respiratory rate >20 breaths per min or PaCO2 <4.3 kPa) or on mechanical ventilation - Abnormal leukocyte count (>12,000/<4000 cells/mm3)

Study Disclaimer Statement