LEOPARDS
Trial Details
- Trial statusCompleted
- Study email contactLEOPARDS@imperial.ac.uk
- Chief InvestigatorProf Anthony Gordon
- Project managerDr Farah Al-Beidh
- SponsorImperial College London
- ISRCTN numberISRCTN12776039
- PhaseIIb
Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis
Design and Objective
This is a double-blind randomised placebo-controlled parallel group trial. It will be conducted in multiple general adult ICUs within the UK. The study will recruit 516 patients.
Key inclusion criteria
- Hypotension, despite adequate intravenous fluid resuscitation, requiring vasopressor infusion AND two of the following: - Fever (>38C) or hypothermia (<36C) - Tachycardia (heart rate >90 bpm) - Tachypnoea (respiratory rate >20 breaths per min or PaCO2 <4.3 kPa) or on mechanical ventilation - Abnormal leukocyte count (>12,000/<4000 cells/mm3)