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Trial Details

  • Trial statusCompleted
  • Study email contactMOTION@imperial.ac.uk
  • Chief InvestigatorDr Parind Patel
  • Project managerAisha Anjum
  • SponsorImperial College Academic Health Science Centre
  • ISRCTN numberISRCTN75305839
  • PhaseIV

Methylnaltrexone for the Treatment of Opioid Induced Constipation & Gastro-Intestinal Stasis in Intensive Care Patients

Design and Objective

This is an interventional, double blind randomized, placebo controlled trial. It will be conducted at the 3 General Intensive Care Units within Imperial College Healthcare NHS Trust. The study will recruit 84 patients.

Key inclusion criteria

- Male/female ≥ 18 years of age - In ICU, sedated with opioids and on invasive ventilation - Requiring opioids for at least a further 24 hours - Constipated (not opened bowels for at least 48 hours in ICU) - On nasogastric tube feeds - Enteral access for administration of medications - Patient weight of 38-114kg

Study Disclaimer Statement