MOTION
Trial Details
- Trial statusCompleted
- Study email contactMOTION@imperial.ac.uk
- Chief InvestigatorDr Parind Patel
- Project managerAisha Anjum
- SponsorImperial College Academic Health Science Centre
- ISRCTN numberISRCTN75305839
- PhaseIV
Methylnaltrexone for the Treatment of Opioid Induced Constipation & Gastro-Intestinal Stasis in Intensive Care Patients
Design and Objective
This is an interventional, double blind randomized, placebo controlled trial. It will be conducted at the 3 General Intensive Care Units within Imperial College Healthcare NHS Trust. The study will recruit 84 patients.
Key inclusion criteria
- Male/female ≥ 18 years of age - In ICU, sedated with opioids and on invasive ventilation - Requiring opioids for at least a further 24 hours - Constipated (not opened bowels for at least 48 hours in ICU) - On nasogastric tube feeds - Enteral access for administration of medications - Patient weight of 38-114kg